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Intertwined with the targeting of the GI tract for metabolic disease therapy, studies suggest that manipulations of the gut microbiome can directly impact host metabolic homeostasis 9 and influence the success of other treatment options, such as gastric bypass surgery and metformin 6,8,10

On one hand, it mediates the cholinergic anti-inflammatory pathway, which involves inhibiting the production of inflammatory factors by peripheral macrophages through the release of acetylcholine, thereby controlling systemic inflammation (Li et al., 2024)

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The orbital fat, on the other hand, remains relatively stable

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Further studies are needed to understand the effect of GLP-1RAs in other ethnic populations