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However, their opposing pharmacodynamic effects create a clinical conflict: prednisone increases appetite hormones (ghrelin, neuropeptide Y) while GLP-1 agonists suppress these same pathways

New Trends Clin Neuropharmacol 1989;3(4):225-230

Glutathione does protect hepatocytes from oxidative damage during lipid metabolism, but increasing glutathione levels won't override the hormonal signals (insulin resistance, leptin resistance) that drive fat accumulation in the first place

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Although it does not have any carcinogenic and teratogenic effects, it is not recommended for use during pregnancy and lactation periods due to lack of sufficient evidence

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