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Older patients and those experiencing hormonal transitions may need longer treatment courses or ongoing maintenance therapy because their underlying metabolic environment is less forgiving of medication withdrawal

2016 Nov 10;375(19):1834-44

Islet amyloid polypeptide, islet amyloid, and diabetes mellitus

When muscle drops too much during weight loss, patients may experience: Reduced strength Lower energy Poorer exercise tolerance Increased frailty risk Greater chance of weight regain Less favorable body shape after weight loss Reduced metabolic flexibility Higher risk of functional decline with aging This is one reason the term skinny fat has become common in wellness conversations

Ozempic is the brand name for semaglutide , a GLP-1 receptor agonist that works by reducing appetite and promoting weight loss

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