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doi: 10.3389/fimmu.2020.01748 51 DaiJ.WangY.WangH.GaoZ.WangY.FangM.et al

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( 7) Use In Specific Populations Pregnancy:Use of NSAIDs during the third trimester of pregnancy increases the risk of premature closure of the fetal ductus arteriosus

In the real world, however, effectiveness of these medications has been limited by several challenges including lack of medication adherence, risk of rebound weight, and high costs

These inhibitory effects of GLP-1 could be mediated by activation of vagal afferents in the distal small intestine or by hormonal effects on the NTS-DMV circuitry (123)