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The guidelines say BMI over 30 or BMI greater than 27 with a weight-related comorbidity. What constitutes a weight-related comorbidity isnt well-defined, but most physicians consider those to be conditions such as cardiovascular disease, hypertension, diabetes, and hyperlipidemia

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In May 2026, the Centers for Medicare & Medicaid Services (CMS) announced a major new effort to improve access to high-cost weight-loss medications for older Americans

Current research gaps include limited understanding of derivatives long-term safety profiles and metabolic fate

Direct clinical trial data comparing these two therapies does not exist, so personalized guidance based on your health profile remains the safest approach

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