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Some GLP-1 medications have evidence of cardiovascular risk reduction in specific patient groups

Now that modern medicine has made weight loss easier than ever, its hard not to backslide and internalize the message that we should all prioritize being smaller, despite the potential risks to our mental and physical health

Early clinical trials evaluating the efficacy of GLP-1 receptor agonists reported a slightly increased risk of acute pancreatitis with these medications versus placebo or conventional treatment

Adverse Effects Profile (Phase 2 Data) The Phase 2 NEJM 2023 trial reported the following adverse event profile

Drugs targeting GPCRs such as GLP-1RA, glucose-dependent insulinotropic polypeptide receptor (GIPR), and melanocortin-4 receptors (MC4R) have been approved for weight management and T2D (2, 3)