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While depression isn't a known side effect, some users have reported mood changes

This may also imply that these drugs are most beneficial when used in conjunction with other interventions, such as lifestyle changes or other medications. The study also confirmed past research findings detailing the drugs potential to lower the risk of heart attack, stroke and other cardiovascular concerns

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doi:10.2991/jegh.k.201217.001 Heart Disease and Stroke Statistics2023 Update: A Report From the American Heart Association