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Phase 2 trial data for the CagriSema combination (cagrilintide 2.4mg + semaglutide 2.4mg) demonstrated approximately 15.6% mean weight reduction at 32 weeks substantially exceeding semaglutide alone and positioning amylin/GLP-1 dual agonism as a competitive research frontier alongside GIP/GLP-1 and triple agonist approaches

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doi:10.1016/j.fct.2013.03.024

Treatment of diet-induced obese mice produced significant reductions in fat mass without affecting lean mass or food intake, suggesting effects on energy expenditure rather than appetite suppression