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Ice crystal formation disrupts peptide structure and can cause permanent aggregation

The evidence suggests that quercetin also controls other transporters involved in uric acid management, including organic anion transporters (OAT1), organic cation transporters (OCT1, OCT2), and organic cation/carnitine transporters (OCTN1, OCTN2) [12]

Deng Z, Meng C, Huang H, Song S, Fu L, Fu Z

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These mutations result in either the absence or reduced production of -globin chains

The correct recognition position docks the disulfide group of GSSG close to the appropriate thiolate group of a deprotonated catalytically active cysteine residue, which is the actual reducing agent of the disulfide group, operating by trans-sulfuration