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All cellular macromolecules are susceptible to oxidative harm

Molecular targets implicated in the antiparasitic and anti-inflammatory activity of the phytochemical curcumin in Trichomoniasis

However, in tauopathies such as AD, as well as in hibernation, tau undergoes hyperphosphorylation catalyzed by various protein kinases, including but not limited to glycogen GSK3, cyclin-dependent kinase 5 (CDK5), and protein kinase A (PKA) [103,104,105], accumulating an excess of 7-10 phosphate groups [106]

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