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ERR in particular is highly expressed in tissues with high energy demands, including heart, skeletal muscle, brown adipose tissue, and kidney, where it coordinates the expression of metabolic gene networks
Patients report dramatic benefits, but we cannot easily separate signal from placebo, concurrent rehab changes, rest, or natural recovery
doi: 10.3389/fphar.2021.718147 Received 09 June 2021 Accepted 17 November 2021 Published 13 December 2021 Volume 12 - 2021 Edited by Fan Jiang, Shandong University, China Reviewed by Dechang Chen, Shanghai Jiao Tong University, China Ying Li, Xian Jiaotong University, China Updates Copyright 2021 Tepes, Gojkovic, Krezic, Zizek, Vranes, Madzar, Santak, Batelja, Milavic, Sikiric, Kocman, Simonji, Samara, Knezevic, Barisic, Lovric, Strbe, Kokot, Sjekavica, Kolak, Skrtic, Seiwerth, Boban Blagaic and Sikiric