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Reported and Observed Side Effects Injection site reaction: Small, brief redness or mild soreness at the injection site

Progestin-containing birth control methods including pills, injections, hormonal IUDs, and vaginal ringscan trigger or worsen APD symptoms , particularly in people with exogenous progesterone hypersensitivity

Potent antioxidants like Vitamins C and E may help in retaining hydration of the skin through preventing the destruction of elastin and collagen

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Folate is a co-factor for enzymes that regulate DNA synthesis and methylation, and is more directly involved in these processes than B12---making it vital for proper gene expression as well as cell growth, repair, and division, especially during periods of rapid growth like pregnancy