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For example, gomisin A induced apoptosis in colon carcinoma HCT-116 cells via caspase-7 activation [79] and inhibited cell proliferation via cell cycle arrest in HeLa cells exposed to TNF- [80]

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Additionally, one study indicated that HMGB1 can upregulate heme oxygenase 2 and transferrin expression through the RAS-JNK/p38 pathway, promoting erastin-induced ferroptosis [101]

Reduce dose or split into smaller, more frequent injections

Understanding Thalassemia Treatment Thalassemia is a genetic blood disorder characterized by the impaired production of hemoglobin

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