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Along with widely accepted conventional mechanism of desensitization, studies of various GPCRs including dopamine D2-like receptors (D 2 R, D 3 R, D 4 R) have suggested the existence of another desensitization mechanism

Similar to the codes effective October 1, 2025, the proposed APC assignments and status indicators for these new Level II HCPCS codes that will be effective January 1, 2026, will also be subject to comment in the CY 2027 OPPS/ASC proposed rule, and will be finalized in the CY 2027 OPPS/ASC final rule with comment period

A final APC and payment rate are assigned as shown in Addendum B to this final rule with comment period

References [1] Novo Nordisk

Individualized targets: Glycemic targets should be individualized to balance efficacy and safety, particularly in patients with advanced disease or multiple comorbidities

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