glp 1 for chronic inflammation GLP-1 Agonists in Cardiovascular Diseases: Mechanisms, Clinical Evidence, and Emerging Therapies GLP-1 Receptor Agonists as Emerging

GLP-1 has several extra-pancreatic properties which include effects on kidney function

Alcohol creates new damage faster than the peptide can repair old damage

Viegas CM, Zanatta , Grings M, Hickmann FH, Monteiro WO, Soares LE, Sitta , Leipnitz G, de Oliveira FH, Wajner M (2014) Disruption of redox homeostasis and brain damage caused in vivo by methylmalonic acid and ammonia in cerebral cortex and striatum of developing rats

Contributing factors include: reduced nutritional intake (proteins, essential amino acids, competition between amino acid transporters, vitamin insufficiency [riboflavin: GSSG reductase, nicotinic acid: NADPH, pyridoxine (B 6 ): SAMe pathway], mitochondrial dysfunction: ATP deficiency, down regulation SAMe synthase, oxidation of SAMe pathway enzymes, enhanced GSH utilization: conjugation reactions (toxins, drugs), and overwhelming oxidative challenge

Louis was terrific

Focus on bioavailability: Look for liposomal delivery to ensure absorption