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Timing considerations when switching medications If you are switching from semaglutide to tirzepatide or going the other direction , timing the transition correctly matters

89 This seems counterproductive as during the fasting state adipocytes need to release stored fat and it is likely glucagon action promotes net lipolysis in adipocytes- perhaps adiponectin reduces the rate of lipolysis to stop hyperlipidaemia

This gives your body a few extra weeks to adjust and can make a massive difference in your daily comfort

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Can you lose muscle on GLP-1 medications

For example, co-morbid conditions like hyperlipidemia could tip the scale and make one drug more suitable for a specific patient