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(PubMed) Collins R, Peto R, Armitage J

Kirkman (University of North Carolina, Chapel Hill, NC), S

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Moreover, the combination of differentiation and hypoxia induces even more oxidative stress, possibly because hypoxia induces mitochondrial ROS production and stimulates reductive carboxylation of glutamine, thereby increasing the NADPH demand 28,29

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This study has several strengths, including its prospective design, inclusion of both diabetic and non-diabetic control groups, and rigorous methodology with blinded imaging review