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Importantly, this suppression is also glucose-dependentglucagon responses to hypoglycemia remain intact, preserving a critical protective mechanism

Participants either followed an exclusion diet, defined as gluten and casein free regimen adopted independently by families before enrolment, or an unrestricted die, an important source of baseline heterogeneity, as dietary patterns were not experimentally assigned

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In further studies, lipopolysaccharide (LPS)-induced changes in keratinocyte viability, apoptosis, and increased expression of inflammatory cytokines such as TNF- , IL-6, and IL-8 can be reversed by SIN intervention