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Nonclinical studies in rodents of clinically relevant doses of GLP-1 receptor agonists showed dose-related and treatment-duration-dependent increases in the incidence of thyroid C-cell tumors (adenomas and carcinomas)

Generalizing these findings to healthy adults requires significant caution

doi:10.1371/journal.pone.0008545 Walker, Patricia Frye, and Elizabeth D

In a study screening commercial and experimental CYP51A1 inhibitors for anti-cancer activity, only VFV, a compound with a bulky imidazole-oxadiazole core, showed potent anti-proliferative effects across multiple cancer cell types

Fatigue while on tirzepatide may not be solely due to the medication itself

For example, a 1 mL solution with 1000 mcg/mL is the same as 1 mg/mL