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Finally, the alternative first exon (E1b) encodes the N-terminal part of the nuclear isoform, n-GPx4, and contains a nuclear targeting sequence which is apparently retained after nuclear import (Pfeifer et al., Figure 1 Unexpected DHA-induced transcriptional regulation of Gpx4 gene We have recently reported that DHA upregulates several members of both glutathione/glutaredoxin and thioredoxin/peroxiredoxin antioxidant systems in mouse hippocampal HT22 cells (Casaas-Snchez et al., Gpx4 isoforms, around 150%, and affecting all transcripts analyzed, including the mitochondrial, cytosolic, and nuclear isoforms

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