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Lancet (2009) 374:160616

Moreover, GIP has been found to boost glucose uptake by improving insulin sensitivity in adipocytes (176, 177), while tirzepatide has been demonstrated to enhance insulin sensitivity and promote glucose disposal in white adipose tissue in Glp-1r-null mice (178), further supporting a direct effect of GIP on adipose tissues

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Nauck MA et al (2011): Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans

Retrieved from Perkovic, V., Tuttle, K

Not everyone, however, was persuaded by Marks and Samols' results