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In another RCT ( n = 80), prolonged-release melatonin (PRM 2-mg) therapy showed a significant improvement in sleep hours and reduction in delirium episodes among hospitalized insomniac COVID-19 patients 668

doi: 10.1530/EJE-16-0467 [DOI] [PubMed] [Google Scholar] 29

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Notably in the latter cohort, 2 patients injected weekly formulations daily for 12 and 14 days and one patient injected semaglutide 0.5 mg twice a day for 1 month