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To generate sufficient quantities of ROS and RNS quickly, these cells require rapid flux through the PPP to produce sufficient amounts of NADPH to enable superoxide formation from oxygen by the action of NADPH oxidase (NOX), and nitric oxide (NO) formation from arginine by inducible nitric oxide synthase (iNOS) ( Figure 1A-2 )

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In sepsis models, it reduces mortality and improves immune responsiveness

Some individuals may have reduced capacity to produce glutathione via the transsulfuration pathway, making supplementation theoretically relevant

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