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Stage 2 skin is uneven with indentations (like cellulite) representing thickening and contraction of underlying connective tissue fibers over increased fat with small to larger hypodermal masses

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Using complex CRC GEMMs with proficient immune signalling, we demonstrate an increase in cell death and survival in these heterogeneous tumours, more akin to a tumour histology than xenograft or PDX counterparts 21,78

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