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In addition to ESCs, cardiac progenitor cells (CPCs) from diabetic patients have been shown to exhibit decrease enzymatic activity of not only G6PD, but also transketolase (TKT) another NRF2 target gene ( NRF2 has also been shown to play an important role in overseeing mitochondrial biogenesis and metabolism, although direct confirmation of target genes involved in these processes has been lacking (Piantadosi et al., 2008)

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