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The cloning of GHS-R1a revealed a novel mechanism for regulating growth hormone secretion through ghrelin receptor pathways. Smith , Endocrinology This discovery paved the way for peptides like GHRP-6, which can enhance endogenous GH pulses providing an alternative to the flat, non-pulsatile elevation seen with exogenous Human Growth Hormone (HGH) administration

The third binding site is the Arrestin box, which binds (L/I) 2 GxL motifs from a splice variant of Arrestin 2 19

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