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Nordestgaard, Brge G., et al

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That dual mechanism is why tirzepatide is studied as its own category

Wellcome)

For example, metformin primarily reduces liver glucose production, while semaglutide is a GLP-1 receptor agonist that stimulates insulin release

One further nuance worth noting: the addition of GIP in both tirzepatide and retatrutide is hypothesised to improve gastrointestinal tolerability relative to GLP-1 alone at comparable efficacy