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Similar patterns of FTH1 upregulation and TfR1 downregulation have also been reported in primary murine chondrocytes under iron overload (93) and in cartilage tissue from OA models (94)

Matrix metalloproteinases and collagen catabolism[J]

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doi: 10.3390/ijms26031098

Dysfunction in the gut barrier (intestinal hyperpermeability or leaky gut) appears in most autoimmune conditions, potentially serving as both a trigger for initial autoimmune development and a perpetuating factor that maintains immune dysregulation

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