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The active site of most classical PTPs is formed by the P-loop, which contains the conserved PTP signature motif (H/V)C(X) 5 R(S/T)

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2 Characteristics of Th17 cells and Treg cells Th17 and Treg cells, despite their shared origin in nave CD4 + T cells, undergo divergent differentiation fates dictated by antagonistic transcriptional and cytokine networks