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We have included all data separated by sex in Supplemental Figure 6

In HFD-fed KK-Ay mice, L-carnitine administration inhibited Srebp1c mRNA overexpression while increasing -hydroxybutyrate levels, suggesting concurrent lipogenesis suppression and -oxidation activation ( Hmgcr, Srebp2, Pcsk9, Ldlr ) in HFD-fed mice

for this reason, initial patient enrollment goals were not designed to power statistical comparisons but were driven by availability of smaller patient subgroups within the study (e.g., treatment-experienced patients with cirrhosis)