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When normality was met and there were unequal variances, a Welchs t -test, a Welchs one-way ANOVA or an adjusted Welch version of the two-way ANOVA using trimmed means was used when testing two groups, more than two groups with one variable or two independent variables, respectively 52

In addition, the binding of HSC70 to clathrin-operating enzyme (cyclin G-associated kinase) has been demonstrated to be the key milestone in the regulation of clathrin-mediated endocytosis (He et al., 2025)

It reduces the production of tyrosinase enzyme, which is essential for the synthesis of melanin

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