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In contrast, APOE4 has been consistently linked to increased risk and earlier onset of Alzheimers disease (AD), possibly due to its detrimental influence on lipid homeostasis, mitochondrial integrity, and neuroinflammatory pathways (Volgman et al., 2024

2024;16(9):e70279

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Tirzepatide, the active compound in Mounjaro, is actually a GIP/GLP-1 receptor agonistmeaning it targets two hormone pathways instead of one

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E., Imai, K., King, G