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IGF-1-independent metabolic-pathway research

300 L diluted PMNs were pre-incubated with vehicle (DMSO), Zileuton (an inhibitor of 5-LOX), and GPX4 activator at 37C for 15 min, respectively

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May 30 2020;21(11)doi:10.3390/ijms21113943

Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms

Third, and perhaps most relevant, it promotes fibroblast migration and collagen synthesis , the exact cellular processes needed to rebuild the damaged annulus fibrosus