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B 2018, 32 (18), 1840009

It has been documented that iodide excess increases the generation of ROS and ICAM-1 expression in cultures of NOD.H2 h4 mouse thyrocytes, and that the antioxidant diphenyleneiodium, an inhibitor of NADPH oxidase, reduced both phenomena [177]

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ROS directly damage membrane lipids, triggering lipid peroxidation, while the ERR-GLS1 axis regulates the ability of GPX4 to clear lipid peroxides by modulating the GSH/GSSG ratio (97)