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Specifically, the active constituents were found to inhibit cancer cell growth and metastasis by affecting mitochondrial function, regulating the expression of apoptosis-related proteins, and interfering with cell signaling pathways such as PI3K/AKT, AMPK, MAPK, and EGFR

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Blood 122:14551463 Laguzza BC, Nichols CL, Briggs SL, Cullinan GJ, Johnson DA, Starling JJ, Baker AL, Bumol TF, Corvalan JR (1989) New antitumor monoclonal antibody-vinca conjugates LY203725 and related compounds: design, preparation, and representative in vivo activity