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As you can probably tell from the name, glutamic acid makes glutathione an acid, and there is not a corresponding basic amino acid (lysine or arginine) in glutathione to neutralize it

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Besides, MTX treatment causes DNA strands to break in intestinal epithelial cells that proliferate quickly (Sonis 2004) and induces oxidative stress (El-Sheikh et al

Lee SR, Lee JC, Kim SH, Oh YS, Chae HD, Seo H, Kang CS, Shin TS (2021) Altered composition of microbiota in women with ovarian endometrioma: microbiome analyses of extracellular vesicles in the peritoneal fluid

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