A 2025 Springer review on the topic confirmed that women with PCOS face unique metabolic challenges, including heightened insulin resistance, compounded by obesity that require targeted, not generic, interventions
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By modulating the balance between the serotonin and kynurenine pathways, tryptophan helps regulate the immune response during stress, preventing excessive inflammation that could lead to tissue damage [55]
Evidence from the SURPASS phase III clinical trial program has consistently demonstrated the superior metabolic efficacy of tirzepatide compared with currently available GLP-1 receptor agonists, such as semaglutide
