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Ice crystals form and physically damage the peptide chains

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USA 58 , 199205 (1967)

Aigner, T., Sachse, A., Gebhard, P

References 1 New England Journal of Medicine (2023)Triple-Hormone-Receptor Agonist Retatrutide for Obesity (Phase 2 trial

As GLP-1 receptor agonists, these peptide drugs mimic the incretin hormone GLP-1, enhancing glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and reducing appetite [9]