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A significant portion of ER glutathione is oxidized, with a [GSH]/[GSSG] ratio that can reach 3:1

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Based on this methodology, using the most recent data available for this final rule with comment period, we trended the $630 threshold forward and rounded the resulting dollar amount ($656.65) to the nearest $5 increment, which yields a final diagnostic radiopharmaceutical packaging threshold figure of $655 per day for CY 2026

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