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The review further distinguishes between established outcome benefits (CVD, CKD, and OSA) and conditions still under investigation (neurodegeneration, arthritis, and some liver endpoints)

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Clin Genitourin Cancer 10(4):225231 Bailey EB, Tantravahi SK, Poole A et al (2015) Correlation of degree of hypothyroidism with survival outcomes in patients with metastatic renal cell carcinoma receiving vascular endothelial growth factor receptor tyrosine kinase inhibitors

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Once frozen, the solution loses all therapeutic value and cannot be recovered by thawing