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Due to the observed disparity in male-to-female ratios between the two groups, we decided to employ the robust linear mixed-effects model (LME)

Since senescent cells may release a senescence-associated secretory phenotype, the authors suggest that lowering the senescent cell burden may reduce pro-fibrotic signaling in the surrounding cells

Mitochondrial pyruvate carrier 1 (MPC1), an inner membrane protein that transfers pyruvate into mitochondria, is differentially expressed in normal and cancer cells, and inhibition of MPC1 expression can prompt a shift towards EMT in cancer cells