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doi: 10.1001/jamacardio.2018.0022 20 GuhDPZhangWBansbackNAmarsiZBirminghamCLAnisAH

Importantly, DSIP does not appear to generate the same type of dependency observed with opioid-based agents, despite some overlap in receptor pathways within the nervous system

For example, while low-dose polyphenols stimulate endogenous antioxidant defenses, high concentrations, such as those found in concentrated supplements, can act as potent pro-oxidants, leading to increased oxidative stress and cellular damage 51

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