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However, our approach is a significant advance on these earlier methods, for the following reasons: snap-freezing of samples followed by reaction with IAM-TPP/IAM enables us to trap and stablise all reactive sulfur species simultaneously through their nucleophilic reactions to generate stable products, rather than leaving labile moieties that may be modified during sample workup

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however, several ancestry-specific signals were markedly attenuated when combining populations, likely reflecting heterogeneity in allele frequencies and LD patterns

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