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Reductions in body weight were significantly greater with the LY3298176 1.5 mg, 4.5 mg and 10 mg doses versus placebo in MAD HS (LSM difference [95% CI]: -1.75 kg [-3.38, -0.12], -5.09 kg [-6.72, -3.46] and -4.61 kg [-6.21, -3.01], respectively) and doses of 10 mg and 15 mg had a relevant effect in T2DM patients (LSM difference [95% CI]: -2.62 kg [-3.79, -1.45] and -2.07 kg [-3.25, -0.88], respectively

J Investig Dermatol 128:18211829 Funding Funding was not available for this study

Treatment was well tolerated without reported side effects

Human Behavior and Cognitive Patterns Examining the often-unconscious mechanisms that guide human choice-how we navigate uncertainty, balance logic with intuition, and adapt through seemingly irrational behavior

A one-week titration at 1 mg may improve tolerability before advancing to the full 2 mg dose

Trends Neurosci 33 : 103109