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It is important to note that these medications are not specifically weight-loss drugs

The non-coenzyme action of thiamine in neurotransmission is further supported by the action of the thiamine analog oxythiamine, whose diphosphorylated derivative (oxyThDP), formed by TPK in vivo , is an antagonist of the coenzyme action of thiamine

Nat Med 28(10):20832091

Regular assessment should include glycemic control (A1C every three months initially), weight trends, gastrointestinal tolerability, and screening for potential complications

Rowe R.C., Sheskey P.J., Quinn M.E