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Duarte-Zambrano F, Barrero JA, Mockus I (2023) Cerebrospinal fluid levels of hypothalamicpituitary-adrenal axis hormones in MCI and dementia due to Alzheimers disease: a systematic review

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The subgroup treated with the maximum dose of tirzepatide lost an average of 22.5% of their body weight (approximately 24 kg) and 63% of subjects lost at least 20% of their body weight

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High dose (100+ g/kg): Increased incidence of joint swelling, carpal tunnel risk, and more pronounced metabolic effects