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Stability in aqueous nasal spray form is a real and under-discussed problem: no published stability data exist for commercial nasal formulations of BPC-157

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In the context of surgery, prophylactic DNase might reduce postoperative SIRS (though could have potential side effect of impairing host defense against infection, so careful balance needed)

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The anti-fibrotic properties of Klotho are attributed to its ability to suppress FGF activity and to regulate Wnt signaling pathways (Portales-Castillo et al., 2022