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It signals that the approved use is chronic management rather than a defined course with an end date, which reframes the question from "how long until I finish" to "how long until the trajectory is established, and what happens after." An Intermediate Marker Around Five Months The clearest published mid-course number comes from STEP 4, which used a 20-week run-in 16 weeks of dose escalation plus four weeks at the maintenance dose before randomizing participants

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Blood levels of glutathione increased after one month at both dosages, although the increase was more at the higher dose