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Comparison of the efficacy and safety of 10 glucagon-like peptide-1 receptor agonists as add-on to metformin in patients with type 2 diabetes: a systematic review

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10.1123/ijspp.2013-0207 98

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Pharmacological research demonstrates several mechanisms contributing to this selectivity: High Receptor Affinity: Ipamorelin binds to GHSR-1a receptors with high affinity, triggering intracellular signaling cascades associated with GH secretion

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