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10.1038/s43018-021-00287-5 95 MeiheL.ShanG.MinchaoK.XiaolingW.PengA.XiliW.et al (2021)

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Side Effects and Tolerability at .25 Semaglutide The .25 mg dose produces mild to moderate side effects in most peoplenausea is most common, followed by constipation and reduced appetite for certain foods (which is actually the therapeutic goal)

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Weeks 78 (taper) + 24 week washout: reduce to 200 mcg/day for final week, then pause